Targeted Therapy for Gut Microbiota: Candidates for a Novel Strategy to Ameliorate Type 2 Diabetes MellitusIF:6.7

Studies have demonstrated that Alistipes finegoldii can reduce postprandial blood glucose in mice, and Alistipes indistinctus exhibits a similar hypoglycemic effect. Moreover, compared to A. finegoldii, A. indistinctus improves IR and body weight (Takeuchi et  al.  2023). Blautia shows comparable effects, as both Blautia producta and Blautia wexleraeeffectively prevent obesity, reduce weight gain and fat accumulation, while simultaneously reducing blood glucose and 
insulin levels, and lowering the homeostasis model assessment of IR (HOMA-IR) index score compared with mice on a normal diet (Hosomi et  al.  2022; Guo, Gao, et  al.  2024). 
Lactobacillus, a genus comprising over 200 species, refers to a group of bacteria that metabolise sugars such as glucose into lactic acid. In both clinical and animal studies, different 
Lactobacillus strains have been found to reduce blood glucose, haemoglobin A1c (HbA1c), and cholesterol levels, and improve IR (Zhong et  al.  2024; Yao et  al.  2019; Wu, Zhang, et al. 2021; Dang et al. 2018; Hsieh et al. 2018). Lactobacillusupregulates the expression of glucagon-like peptide-1 (GLP-1) and interleukin (IL)-10 in patients with obesity or T2DM and suppresses lipid accumulation in adipocytes (Kim et al. 2019; Alard et  al.  2021). Furthermore, Lactobacillus fermentumMCC2760 increased the expression of glucose transporter type 4 (GLUT4), GLP- 1, and zonula occludens- 1 (ZO- 1), thereby im-proving glucose tolerance in mice fed a high- fat diet (Archer et al. 2021). Lactobacillus paracasei L14 and Lactobacillus gas-seri CKCC1913 ameliorated T2DM- related metabolic health by reducing oxidative stress and inflammatory responses (Zeng et  al.  2023). Lactobacillus plantarum HAC01 and L. paraca-sei IMC 502 alleviated hyperglycaemia by preserving pancre-atic β-cell function and modulating glucose metabolism (Lee, Lee, et al. 2021; Gu 
et al. 2023). Lactobacillus salivarius AP- 32 and Lactobacillus reuteri GL- 104 rapidly consumed hexoses.感谢广东省药物制剂研究与评价重点实验引用文献