Double-strand DNA break repair: molecular mechanisms and therapeutic targets

The MRN complex is at the heart of an intricate network
that detects damaged DNA and eventually encourages
its repair by activating signaling pathways. In particular,
the activation of the signal transduction cascade passing
through the cell cycle checkpoints is greatly aided by the
DSB sensor, MRN complex. Additionally, it is essential for
controlling the choice of repair pathways and the DNA
repair procedure carried out by NHEJ and HR. Understanding this complex’s operations will help clarify the
conditions necessary to sustain genomic integrity.41

​感谢中国湖南省衡阳市华南大学衡阳医学院；北京放射医学研究所北京放射生物学重点实验室辐射生物学系（中国北京）引用文献